Cyanocobalamin

Best

Antioxidant

Cyanocobalamin at a glance

  • Synthetic form of Vitamin B12
  • Helps relieve sensitive and stressed skin
  • Protects against skin barrier damage

Cyanocobalamin description

Cyanocobalamin is a synthetic form of vitamin B12 (aka cobalamin), an important water-soluble vitamin that the body needs but cannot produce. Within the body, vitamin B12 is involved in red blood cell production, brain and nerve health and DNA synthesis. Naturally found in liver, oily fish, eggs and dairy products, this vitamin is also and most often used in oral supplements to treat vitamin deficiencies. Some foods, such as breads and cereals, are fortified with this essential nutrient. Vitamin B12 levels are linked to skin, hair, and nail health; indeed, people who have B12 deficiencies — or sometimes excess levels of this vitamin — can experience health complications, including acne. For skin, both oral and topical cyanocobalamin have been used to help prevent or reduce the occurrence of dermatological conditions such as atopic dermatitis and psoriasis, because of this vitamin’s ability to counter factors within skin that cause signs of irritation, especially for people with dry, itchy, or scaly skin. Studies from a major supplier of this ingredient in cosmetics plus additional independent research have shined a light on vitamin B12’s helpful role in defending skin from external stressors (including UV light) and supporting the skin’s microbiome. However, more research needs to be completed and this ingredient is not an approved UV active. Commercial vitamin B12 is mainly produced through bacterial fermentation. Use levels of cyanocobalamin in cosmetics typically range from 0.5–5%.

Cyanocobalamin references

  • Journal of Clinical and Aesthetic Dermatology, March 2024, pages 34–41
  • International Wound Journal, February 2023, pages 516-528
  • American Journal of Clinical Dermatology, February 2015, pages 27-33
  • British Journal of Dermatology, May 2004, pages 977-983

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings

Best

Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.

Good

Necessary to improve a formula's texture, stability, or penetration.

Average

Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.

Bad

There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.

Worst

May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.

unknown

We couldn't find this in our ingredient dictionary. We log all missing ingredients and make continuous updates.

Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.