Sh-Polypeptide-123

Sh-polypeptide-123 is an anti-aging recombinant (recombined protein) human peptide used in skin care that’s created through fermenting a form of yeast called _Pichia pastoris_ (AKA _Komagataella pastoris_). It’s a biomimetic ingredient that resembles the human collagen alpha-1 (III) chain, a crucial component of type 3 collagen, the second most abundant type in skin. Recombinant human peptides are exciting ingredients touted to support healthy collagen production and tensile strength, resulting in a visible reduction in the appearance of fine lines and wrinkles, a decrease in visible skin laxity, improved skin firmness, smoother skin and improved hydration. Although their benefits are impressive, the way they’re created is a true feat of science. Chemists use bioengineering practices to extract a “code” for a desired DNA sequence into a vector, a particle that can replicate in a host cell. In the case of sh-polypeptide-123, this is the code for collagen alpha-1 (III). Then, this vector containing code is introduced into a host cell (for sh-polypeptide-123, it’s _Pichia pastoris_ yeast cells) and fermented. These host cells are then purified and prepared for use in cosmetics as well as supplements. Voilà! You have a recombinant human peptide! Many recombinant human peptides are used in skin care and have research supporting their use, however, research supporting sh-polypeptide-123 is limited with few objective studies outside of cosmetic supplier info. Suppliers of this ingredient recommend using it in concentrations between 0.5%-15.0% when included in an ingredient blend with water and glycerin. It appears as a white powder in raw material form.

Related ingredients: Sh-Polypeptide-121 Peptides