Spermidine

Good

Antioxidant

Spermidine at a glance

  • Natural compound in plants, fungi and animals
  • Has potential to regulate aspects of aging skin
  • Proven to deliver skin-soothing benefits
  • May mitigate the appearance of hypopigmentation
  • More research related to topical application is needed

Spermidine description

Spermidine is a naturally occurring compound found in plants, fungi and animals (including humans). It has emerged as a promising ingredient linked to longevity due to its significant role in autophagy, a cellular recycling process responsible for regulating key aspects of aging and health. While current research focuses heavily on oral supplementation and medicinal applications, spermidine shows intriguing potential as an anti-aging skin care ingredient as well. One of the more unique areas of scientific exploration regarding spermidine is its ability to help even out hypopigmentation (diffused or localized patches of skin that appear lighter). Studies also suggest spermidine can strengthen skin’s natural protective barrier, provide collagen support and deliver skin-soothing benefits. Beyond skin benefits, research indicates spermidine has benefits for supporting hair and nail growth when taken in supplement form. While more studies are required to fully understand spermidine’s efficacy in skin care products, the available evidence looks promising. We’ll continue to watch this space and update. Spermidine is typically sourced from plant-based materials like wheatgerm and can be found in relatively high levels in dietary foods such as soybeans (especially a fermented version known as natto) and mushrooms. Note: Cosmetic use of spermidine may be restricted in certain global markets.

Spermidine references

  • CCIH, Accessed October 2024, ePublication
  • Aesthetic Plastic Surgery, May 2024, ePublication
  • International Journal of Molecular Sciences, March 2023, pages 1-25
  • Comprehensive Reviews in Food Science and Food Safety, May 2022, pages 2,820-2,842
  • GeroScience, April 2021, pages 673-690
  • Communications Biology, February 2021, pages 1-11
  • Applied Sciences, June 2020, pages 1-12
  • Dermatology Practical & Conceptual, October 2017, pages 17-21
  • Gerontology, January 2014, pages 319-326
  • Journal of Investigative Dermatology, February 1996, pages 249-253

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings

Best

Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.

Good

Necessary to improve a formula's texture, stability, or penetration.

Average

Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.

Bad

There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.

Worst

May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.

unknown

We couldn't find this in our ingredient dictionary. We log all missing ingredients and make continuous updates.

Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.